Retrospectively registered, 8 October 2021. Further studies are needed to confirm these findings. The supplementation with d-allulose has the potential to improve postprandial hyperglycemia in patients with T2DM after iftar during Ramadan. The consumption period demonstrated significantly higher percentages of time in which glucose values were found in the target range ( p = 0.0032), and when the glucose levels above the target range were reduced ( p = 0.0015). Significant lower ( p < 0.01) postprandial glucose values and the glucose incremental area under the curve (iAUC) were observed from 0 to 180 min during the consumption period compared to the control period. ResultsĪ total of 12 participants completed the study. Postprandial glucose was measured using a continuous glucose monitoring system. During the consumption period, 8.5 g of d-allulose was consumed by the participants before iftar meal. The primary outcome was postprandial peak glucose levels. This was a pilot, prospective single-arm study design that was conducted for 10 consecutive days 5 days of control and 5 days of consumption. This study investigates whether d-allulose (a C-3 epimer of d-fructose) improves the postprandial glucose in patients with type 2 diabetes mellitus (T2DM) during Ramadan. d-allulose is a rare sugar and is reported to have several health benefits, including the suppression of increase in postprandial glucose levels. During Ramadan fasting, postprandial hyperglycemia is commonly observed after iftar (break of fast at sunset) meal.
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